Recombinant Human Disks large homolog 5 (DLG5), Truncated

Cat.No	ACP14507	Target Name	DLG5
Form	Lyophilized powder	Expression System	Custom Production. Please inquire and provide the desire expression system.
Protein Length	Partial	Purity	>85% (SDS-PAGE)
Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Cat.No

ACP14507

Target Name

DLG5

Form

Lyophilized powder

Expression System

Custom Production. Please inquire and provide the desire expression system.

Protein Length

Partial

Purity

>85% (SDS-PAGE)

Storage Buffer

5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Target Species	Human	Uniprot ID	Q8TDM6

Background Information

Uniprot Id

Q8TDM6
Target Species

Human
Target Name

DLG5
Target Full Name

Disks large homolog 5
Target Function

Acts as a regulator of the Hippo signaling pathway. Negatively regulates the Hippo signaling pathway by mediating the interaction of MARK3 with STK3/4, bringing them together to promote MARK3-dependent hyperphosphorylation and inactivation of STK3 kinase activity toward LATS1. Positively regulates the Hippo signaling pathway by mediating the interaction of SCRIB with STK4/MST1 and LATS1 which is important for the activation of the Hippo signaling pathway. Involved in regulating cell proliferation, maintenance of epithelial polarity, epithelial-mesenchymal transition (EMT), cell migration and invasion. Plays an important role in dendritic spine formation and synaptogenesis in cortical neurons; regulates synaptogenesis by enhancing the cell surface localization of N-cadherin. Acts as a positive regulator of hedgehog (Hh) signaling pathway. Plays a critical role in the early point of the SMO activity cycle by interacting with SMO at the ciliary base to induce the accumulation of KIF7 and GLI2 at the ciliary tip for GLI2 activation.
Target Subcellular Location

Cell junction. Cell membrane; Peripheral membrane protein. Cell junction, synapse, postsynaptic density. Cytoplasm, cytoskeleton, cilium basal body. Note=Localized at sites of cell-cell contact.
Target Protein Families

MAGUK family
Target Tissue Specificity

Highly expressed in normal breast tissues and low-grade breast cancer tissues (at protein level). Highly expressed in the placenta and prostate. Expressed at a lower level in the thyroid, spinal cord, trachea, adrenal gland, skeletal muscle, pancreas, hea
Target Synonyms

Discs large homolog 5 (Drosophila); Discs large homolog 5; Discs large protein LP DLG; Discs large protein P dlg; Discs large protein P-dlg; Disks large homolog 5; DLG 5; DLG5; DLG5_HUMAN; KIAA0583; Large type of P DLG; LP DLG; P DLG5; PDLG; Placenta and prostate DLG

Recombinant Human Disks large homolog 5 (DLG5), Truncated

Specifications

Immunogen Information

Inquire Recombinant Human Disks large homolog 5 (DLG5), Truncated Now

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