Recombinant Human DNA-directed RNA polymerase I subunit RPA1 (POLR1A), Truncated

Uniprot Id

O95602

Target Species

Human

Target Name

POLR1A

Target Full Name

DNA-directed RNA polymerase I subunit RPA1

Target Function

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic core component of RNA polymerase I which synthesizes ribosomal RNA precursors. Forms the polymerase active center together with the second largest subunit. A single stranded DNA template strand of the promoter is positioned within the central active site cleft of Pol I. A bridging helix emanates from RPA1 and crosses the cleft near the catalytic site and is thought to promote translocation of Pol I by acting as a ratchet that moves the RNA-DNA hybrid through the active site by switching from straight to bent conformations at each step of nucleotide addition.

Target Involvement

Acrofacial dysostosis, Cincinnati type (AFDCIN)

Target Subcellular Location

Nucleus, nucleolus. Chromosome.

Target Protein Families

RNA polymerase beta' chain family

Target Synonyms

A190; AFDCIN; DNA-directed RNA polymerase I largest subunit; DNA-directed RNA polymerase I subunit A; DNA-directed RNA polymerase I subunit rpa1; Polr1a; Polymerase (RNA) I polypeptide A 194kDa; RNA polymerase I 194 kDa subunit; RNA polymerase I subunit A; RNA polymerase I subunit A1; RPA1; RPA1_HUMAN; RPA194; RPO1 4; RPO14