Recombinant Human DNA-directed RNA polymerase II subunit RPB9 (POLR2I)

Uniprot Id

P36954

Target Species

Human

Target Name

POLR2I

Target Full Name

DNA-directed RNA polymerase II subunit RPB9

Target Function

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB9 is part of the upper jaw surrounding the central large cleft and thought to grab the incoming DNA template.

Target Subcellular Location

Nucleus, nucleolus.

Target Protein Families

Archaeal RpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family

Target Synonyms

DNA directed RNA polymerase II 14.5 kDa polypeptide; DNA directed RNA polymerase II polypeptide I; DNA directed RNA polymerase II subunit I; DNA directed RNA polymerase II subunit RPB9; DNA-directed RNA polymerase II subunit I; DNA-directed RNA polymerase II subunit RPB9; hRPB14.5; POLR2I; Polymerase (RNA) II (DNA directed) polypeptide I 14.5kDa; RNA polymerase II 14.5 kDa subunit; RNA polymerase II subunit B9; RPB14.5; RPB9; RPB9_HUMAN

Target Background

This gene encodes a subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. This subunit, in combination with two other polymerase subunits, forms the DNA binding domain of the polymerase, a groove in which the DNA template is transcribed into RNA. The product of this gene has two zinc finger motifs with conserved cysteines and the subunit does possess zinc binding activity.