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| Cat.No | ACP10807 | Target Name | POLG2 |
|---|---|---|---|
| Form | Lyophilized powder | Expression System | Custom Production. Please inquire and provide the desire expression system. |
| Protein Length | Partial | Purity | >85% (SDS-PAGE) |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q9UHN1 |
|---|
Uniprot Id
Q9UHN1
Target Species
Human
Target Name
POLG2
Target Full Name
DNA polymerase subunit gamma-2
Target Function
Mitochondrial polymerase processivity subunit. It regulates the polymerase and exonuclease activities promoting processive DNA synthesis. Binds to ss-DNA.
Target Involvement
Progressive external ophthalmoplegia with mitochondrial DNA deletions, autosomal dominant, 4 (PEOA4)
Target Subcellular Location
Mitochondrion.
Target Research Area
Transcription
Target Synonyms
DNA directed DNA polymerase gamma 2; DNA polymerase gamma accessory 55 kDa subunit; DNA polymerase subunit gamma 2; mitochondrial; DNA polymerase subunit gamma-2; DPOG2_HUMAN; HP55; mitochondrial; Mitochondrial DNA polymerase accessory subunit; Mitochondrial DNA polymerase subunit gamma 2; Mitochondrial polymerase gamma 2; MtPolB; OTTMUSP00000003758; p55; PEOA4; POLB; PolG beta; PolG-beta; POLG2; POLGB; Polymerase (DNA directed); gamma 2; accessory subunit; Polymerase; gamma 2; RP23-247J12.3
Target Background
This gene encodes the processivity subunit of the mitochondrial DNA polymerase gamma. The encoded protein forms a heterotrimer containing one catalytic subunit and two processivity subunits. This protein enhances DNA binding and promotes processive DNA synthesis. Mutations in this gene result in autosomal dominant progressive external ophthalmoplegia with mitochondrial DNA deletions.
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