Recombinant Human DnaJ homolog subfamily C member 9 (DNAJC9)

Uniprot Id

Q8WXX5

Target Species

Human

Target Name

DNAJC9

Target Full Name

DnaJ homolog subfamily C member 9

Target Function

Acts as a dual histone chaperone and heat shock co-chaperone. As a histone chaperone, forms a co-chaperone complex with MCM2 and histone H3-H4 heterodimers; and may thereby assist MCM2 in histone H3-H4 heterodimer recognition and facilitate the assembly of histones into nucleosomes. May also act as a histone co-chaperone together with TONSL. May recruit histone chaperones ASF1A, NASP and SPT2 to histone H3-H4 heterodimers. Also plays a role as co-chaperone of the HSP70 family of molecular chaperone proteins, such as HSPA1A, HSPA1B and HSPA8. As a co-chaperone, may play a role in the recruitment of HSP70-type molecular chaperone machinery to histone H3-H4 substrates, thereby maintaining the histone structural integrity. Exhibits activity to assemble histones onto DNA in vitro

Target Subcellular Location

Nucleus. Cytoplasm. Cell membrane.

Target Tissue Specificity

Expressed in heart, placenta, liver, skeletal muscle, kidney, pancreas, thymus, ovary, colon and peripheral blood.

Target Synonyms

DnaJ homolog subfamily C member 9; DnaJ Hsp40 homolog subfamily C member 9; DnaJ protein SB73; DNAJC9; DNJC9_HUMAN; HDJC9 ; J DOMAIN OF DNAJ LIKE PROTEIN 1; JDD1 ; SB73