Recombinant Human Dual specificity testis-specific protein kinase 1 (TESK1)

Uniprot Id

Q15569

Target Species

Human

Target Name

TESK1

Target Full Name

Dual specificity testis-specific protein kinase 1

Target Function

Dual specificity protein kinase activity catalyzing autophosphorylation and phosphorylation of exogenous substrates on both serine/threonine and tyrosine residues. Regulates the cellular cytoskeleton by enhancing actin stress fiber formation via phosphorylation of cofilin and by preventing microtubule breakdown via inhibition of TAOK1/MARKK kinase activity. Inhibits podocyte motility via regulation of actin cytoskeletal dynamics and phosphorylation of CFL1. Positively regulates integrin-mediated cell spreading, via phosphorylation of cofilin. Suppresses ciliogenesis via multiple pathways; phosphorylation of CFL1, suppression of ciliary vesicle directional trafficking to the ciliary base, and by facilitating YAP1 nuclear localization where it acts as a transcriptional corepressor of the TEAD4 target genes AURKA and PLK1. Probably plays a central role at and after the meiotic phase of spermatogenesis.

Target Subcellular Location

Cytoplasm. Cytoplasm, perinuclear region. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cell projection, lamellipodium.

Target Protein Families

Protein kinase superfamily, TKL Ser/Thr protein kinase family

Target Tissue Specificity

Expressed in podocytes and renal tubular cells in the kidney (at protein level).

Target Synonyms

TESK1; Dual specificity testis-specific protein kinase 1; EC 2.7.12.1; Testicular protein kinase 1