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| Cat.No | ACP11126 | Target Name | DNAH1 |
|---|---|---|---|
| Target Synonyms | DNAH1; DHC7; DNAHC1; KIAA1410; Dynein heavy chain 1; axonemal; Axonemal beta dynein heavy chain 1; Ciliary dynein heavy chain 1; Heat shock regulated protein 1; HSRF-1; hDHC7 | Form | Lyophilized powder |
| Expression System | Custom Production. Please inquire and provide the desire expression system. | Protein Length | Partial |
| Purity | >85% (SDS-PAGE) | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q9P2D7 |
|---|
Uniprot Id
Q9P2D7
Target Species
Human
Target Name
DNAH1
Target Full Name
Dynein axonemal heavy chain 1
Target Function
Force generating protein of cilia required for sperm flagellum motility. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Required in spermatozoa for the formation of the inner dynein arms and biogenesis of the axoneme.
Target Involvement
Spermatogenic failure 18 (SPGF18); Ciliary dyskinesia, primary, 37 (CILD37)
Target Subcellular Location
Cytoplasm, cytoskeleton, cilium axoneme. Cell projection, cilium, flagellum.
Target Protein Families
Dynein heavy chain family
Target Tissue Specificity
Expressed primarily in trachea and testis, 2 tissues containing axonemal structures. Also expressed in brain.
Target Synonyms
DNAH1; DHC7; DNAHC1; KIAA1410; Dynein heavy chain 1; axonemal; Axonemal beta dynein heavy chain 1; Ciliary dynein heavy chain 1; Heat shock regulated protein 1; HSRF-1; hDHC7
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