Recombinant Human Dynein light chain Tctex-type 3 (DYNLT3)

Uniprot Id

P51808

Target Species

Human

Target Name

DYNLT3

Target Full Name

Dynein light chain Tctex-type 3

Target Function

Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Probably binds BUB3 as part of transport cargo. Required for the efficient progression through mitosis.

Target Subcellular Location

Nucleus. Cytoplasm, cytoskeleton. Chromosome, centromere, kinetochore. Note=Colocalizes with BUB3 at kinetochores specifically during prometaphase.

Target Protein Families

Dynein light chain Tctex-type family

Target Synonyms

DYNLT3; TCTE1L; TCTE1XLDynein light chain Tctex-type 3; Protein 91/23; T-complex-associated testis-expressed 1-like

Target Background

This gene encodes a member of a subclass of dynein light chains. The encoded protein homodimerizes and forms the light chain component of the cytoplasmic dynein motor protein complex. This protein may be important for binding dynein to specific cargos including the spindle checkpoint protein BUB3. This protein may also function independently of dynein as a transcriptional modulator. Pseudogenes of this gene are found on chromosomes 2 and 20.