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| Cat.No | ACP17073 | Target Name | RNF123 |
|---|---|---|---|
| Form | Lyophilized powder | Expression System | Custom Production. Please inquire and provide the desire expression system. |
| Protein Length | Partial | Purity | >85% (SDS-PAGE) |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q5XPI4 |
|---|
Uniprot Id
Q5XPI4
Target Species
Human
Target Name
RNF123
Target Full Name
E3 ubiquitin-protein ligase RNF123
Target Function
Catalytic subunit of the KPC complex that acts as E3 ubiquitin-protein ligase. Promotes the ubiquitination and proteasome-mediated degradation of CDKN1B which is the cyclin-dependent kinase inhibitor at the G0-G1 transition of the cell cycle. Functions also as an inhibitor of innate antiviral signaling mediated by DDX58 and IFIH1 independently of its E3 ligase activity. Interacts with the N-terminal CARD domains of DDX58 and IFIH1 and competes with the downstream adapter MAVS.
Target Subcellular Location
Cytoplasm.
Target Synonyms
DKFZp686C2222; E3 ubiquitin protein ligase RNF123; E3 ubiquitin-protein ligase RNF123; FLJ12565; FP1477; Kip1 ubiquitination promoting complex protein 1; Kip1 ubiquitination-promoting complex protein 1; KPC 1; KPC1; MGC163504; RING finger protein 123; RN123_HUMAN; RNF 123; Rnf123; Ubiquitin ligase
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