Home Products Recombinant Human E3 ubiquitin-protein ligase UBR1 (UBR1), Truncated

Recombinant Human E3 ubiquitin-protein ligase UBR1 (UBR1), Truncated

ACP15103

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Specifications

Cat.No	ACP15103	Target Name	UBR1
Target Synonyms	E3 ubiquitin-protein ligase UBR1; JBS; N-recognin-1; ubiquitin protein ligase E3 component n-recognin 1; Ubiquitin-protein ligase E3-alpha-1; Ubiquitin-protein ligase E3-alpha-I; UBR1; UBR1_HUMAN	Form	Lyophilized powder
Expression System	Custom Production. Please inquire and provide the desire expression system.	Protein Length	Partial
Purity	>85% (SDS-PAGE)	Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Immunogen Information

Target Species	Human	Uniprot ID	Q8IWV7

Background Information

Uniprot Id

Q8IWV7
Target Species

Human
Target Name

UBR1
Target Full Name

E3 ubiquitin-protein ligase UBR1
Target Function

E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. May be involved in pancreatic homeostasis. Binds leucine and is a negative regulator of the leucine-mTOR signaling pathway, thereby controlling cell growth.
Target Involvement

Johanson-Blizzard syndrome (JBS)
Target Subcellular Location

Cytoplasm, cytosol.
Target Protein Families

UBR1 family
Target Tissue Specificity

Broadly expressed, with highest levels in skeletal muscle, kidney and pancreas. Present in acinar cells of the pancreas (at protein level).
Target Synonyms

E3 ubiquitin-protein ligase UBR1; JBS; N-recognin-1; ubiquitin protein ligase E3 component n-recognin 1; Ubiquitin-protein ligase E3-alpha-1; Ubiquitin-protein ligase E3-alpha-I; UBR1; UBR1_HUMAN

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Recombinant Human E3 ubiquitin-protein ligase UBR1 (UBR1), Truncated

Specifications

Immunogen Information

Inquire Recombinant Human E3 ubiquitin-protein ligase UBR1 (UBR1), Truncated Now

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