Recombinant Human E3 ubiquitin-protein ligase UBR4 (UBR4), Truncated

Uniprot Id

Q5T4S7

Target Species

Human

Target Name

UBR4

Target Full Name

E3 ubiquitin-protein ligase UBR4

Target Function

E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. Together with clathrin, forms meshwork structures involved in membrane morphogenesis and cytoskeletal organization. Regulates integrin-mediated signaling. May play a role in activation of FAK in response to cell-matrix interactions. Mediates ubiquitination of ACLY, leading to its subsequent degradation.

Target Subcellular Location

Membrane; Multi-pass membrane protein. Cytoplasm. Cytoplasm, cytoskeleton. Nucleus. Note=Concentrates at the leading edge of membrane structures involved in actin motility.

Target Protein Families

UBR4 family

Target Synonyms

600 kDa retinoblastoma protein associated factor; 600 kDa retinoblastoma protein-associated factor; E3 ubiquitin-protein ligase UBR4; KIAA0462; KIAA1307; N-recognin-4; p600; RBAF600; Retinoblastoma associated factor 600 like protein; Retinoblastoma associated factor of 600 kDa; Retinoblastoma-associated factor 600; Retinoblastoma-associated factor of 600 kDa; Ubiquitin protein ligase E3 component n recognin 4; UBR4; UBR4_HUMAN; Zinc finger UBR1 type protein 1; Zinc finger UBR1-type protein 1; Zinc finger, UBR1 type 1; ZUBR 1; ZUBR1