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The expression region of this recombinant Human EEF2 covers amino acids 2-858. This EEF2 protein is expected to have a theoretical molecular weight of 99.2 kDa. The EEF2 protein was expressed in e.coli. The EEF2 gene fragment has been modified by fusing the N-terminal 6xHis tag, providing convenience in detecting and purifying the recombinant EEF2 protein during the following stages.Human elongation factor 2 (EEF2) is a crucial protein involved in the process of translation during protein synthesis. It plays a central role in the elongation phase, where it facilitates the movement of tRNA and mRNA through the ribosome. EEF2 functions by promoting the translocation of the ribosome along the mRNA, allowing the addition of amino acids to the growing polypeptide chain. This GTPase activity of EEF2 is essential for the accurate and efficient synthesis of proteins. Beyond its primary role in translation, EEF2 has been implicated in cellular processes such as apoptosis and regulation of gene expression. Research on EEF2 contributes to the understanding of fundamental cellular mechanisms and can provide insights into diseases related to aberrant protein synthesis.
The expression region of this recombinant Human EEF2 covers amino acids 2-858. This EEF2 protein is expected to have a theoretical molecular weight of 99.2 kDa. The EEF2 protein was expressed in e.coli. The EEF2 gene fragment has been modified by fusing the N-terminal 6xHis tag, providing convenience in detecting and purifying the recombinant EEF2 protein during the following stages.Human elongation factor 2 (EEF2) is a crucial protein involved in the process of translation during protein synthesis. It plays a central role in the elongation phase, where it facilitates the movement of tRNA and mRNA through the ribosome. EEF2 functions by promoting the translocation of the ribosome along the mRNA, allowing the addition of amino acids to the growing polypeptide chain. This GTPase activity of EEF2 is essential for the accurate and efficient synthesis of proteins. Beyond its primary role in translation, EEF2 has been implicated in cellular processes such as apoptosis and regulation of gene expression. Research on EEF2 contributes to the understanding of fundamental cellular mechanisms and can provide insights into diseases related to aberrant protein synthesis.
| Cat.No | ACP04296 | Target Name | EEF2 |
|---|---|---|---|
| Target Synonyms | EEF 2; Eef2; EF-2; EF2; EF2_HUMAN; Elongation factor 2; Eukaryotic translation elongation factor 2; Polypeptidyl tRNA translocase; SCA26 | Form | Liquid or Lyophilized powder |
| Expression System | E.coli | Expression Range | 2-858aa |
| Mol Weight | 99.2kDa | Protein Length | Full Length of Mature Protein |
| Purity | Greater than 90% as determined by SDS-PAGE. | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | P13639 |
|---|
Uniprot Id
P13639
Target Species
Human
Target Name
EEF2
Target Full Name
Elongation factor 2
Target Function
Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
Target Involvement
Spinocerebellar ataxia 26 (SCA26)
Target Subcellular Location
Cytoplasm. Nucleus.
Target Protein Families
TRAFAC class translation factor GTPase superfamily, Classic translation factor GTPase family, EF-G/EF-2 subfamily
Target Research Area
Epigenetics and Nuclear Signaling
Target Synonyms
EEF 2; Eef2; EF-2; EF2; EF2_HUMAN; Elongation factor 2; Eukaryotic translation elongation factor 2; Polypeptidyl tRNA translocase; SCA26
Target Background
This gene encodes a member of the GTP-binding translation elongation factor family. This protein is an essential factor for protein synthesis. It promotes the GTP-dependent translocation of the nascent protein chain from the A-site to the P-site of the ribosome. This protein is completely inactivated by EF-2 kinase phosporylation.
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