Recombinant Human Elongation factor Ts, mitochondrial (TSFM)

Uniprot Id

P43897

Target Species

Human

Target Name

TSFM

Target Full Name

Elongation factor Ts, mitochondrial

Target Function

Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.

Target Involvement

Combined oxidative phosphorylation deficiency 3 (COXPD3)

Target Subcellular Location

Mitochondrion.

Target Protein Families

EF-Ts family

Target Tissue Specificity

Expressed in all tissues, with the highest levels of expression in skeletal muscle, liver and kidney.

Target Synonyms

COXPD 3; COXPD3; EF TS; EF Tsmt; EF-Ts; EF-TsMt; EFTS; EFTS_HUMAN; EFTSMT; Elongation factor Ts; Elongation factor Ts mitochondrial; HGNC12367; mitochondrial; Mitochondrial elongation factor Ts; Ts translation elongation factor mitochondrial; TSFM; TSMT

Target Background

This gene encodes a mitochondrial translation elongation factor. The encoded protein is an enzyme that catalyzes the exchange of guanine nucleotides on the translation elongation factor Tu during the elongation step of mitchondrial protein translation. Mutations in this gene are associated with combined oxidative phosphorylation deficiency-3 syndrome. Alternate splicing results in multiple transcript variants.