Recombinant Human Eosinophil peroxidase (EPX)

Uniprot Id

P11678

Target Species

Human

Target Name

EPX

Target Full Name

Eosinophil peroxidase

Target Function

Mediates tyrosine nitration of secondary granule proteins in mature resting eosinophils. Shows significant inhibitory activity towards Mycobacterium tuberculosis H37Rv by inducing bacterial fragmentation and lysis.

Target Involvement

Eosinophil peroxidase deficiency (EPXD)

Target Subcellular Location

Cytoplasmic granule. Note=Cytoplasmic granules of eosinophils.

Target Protein Families

Peroxidase family, XPO subfamily

Target Research Area

Cancer

Target Synonyms

Eosinophil peroxidase [Precursor]; Eosinophil peroxidase; Eosinophil peroxidase heavy chain; EPER; EPO; EPP; EPX; EPX PEN; PERE; PERE_HUMAN

Target Background

This gene is a member of the peroxidase gene family and is expressed in eosinophils. The encoded preproprotein is proteolytically processed into covalently attached heavy and light chains to form the mature enzyme, which functions as an oxidant. The enzyme is released at sites of parasitic infection or allergen stimulation to mediate lysis of protozoa or parasitic worms. The gene is found in a gene cluster with other peroxidase genes on chromosome 17. Mutations in this gene result in eosinophil peroxidase deficiency.