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The recombinant Human HSD17B11 was expressed with the amino acid range of 20-300. The theoretical molecular weight of the HSD17B11 protein is 46.8 kDa. Expression of this HSD17B11 protein is conducted in e.coli. The N-terminal 6xHis-SUMO tag was fused into the coding gene segment of HSD17B11, making it easier to detect and purify the HSD17B11 recombinant protein in the later stages of expression and purification.Human Estradiol 17-beta-dehydrogenase 11 (HSD17B11) is an enzyme involved in the conversion of estrone to estradiol, a key step in estrogen biosynthesis. HSD17B11's main role in steroid hormone metabolism positions it as a significant player in endocrine regulation. In medical and reproductive research, studying HSD17B11 provides insights into hormone-related conditions and potential therapeutic targets for estrogen-dependent diseases. Its involvement in cancer progression implicates HSD17B11 in oncology research, offering avenues for targeted therapies. Investigating HSD17B11 spans endocrinology, reproductive medicine, and oncology, contributing to a comprehensive understanding of hormone dynamics and presenting opportunities for developing therapeutic strategies for hormone-related disorders and cancers.
The recombinant Human HSD17B11 was expressed with the amino acid range of 20-300. The theoretical molecular weight of the HSD17B11 protein is 46.8 kDa. Expression of this HSD17B11 protein is conducted in e.coli. The N-terminal 6xHis-SUMO tag was fused into the coding gene segment of HSD17B11, making it easier to detect and purify the HSD17B11 recombinant protein in the later stages of expression and purification.Human Estradiol 17-beta-dehydrogenase 11 (HSD17B11) is an enzyme involved in the conversion of estrone to estradiol, a key step in estrogen biosynthesis. HSD17B11’s main role in steroid hormone metabolism positions it as a significant player in endocrine regulation. In medical and reproductive research, studying HSD17B11 provides insights into hormone-related conditions and potential therapeutic targets for estrogen-dependent diseases. Its involvement in cancer progression implicates HSD17B11 in oncology research, offering avenues for targeted therapies. Investigating HSD17B11 spans endocrinology, reproductive medicine, and oncology, contributing to a comprehensive understanding of hormone dynamics and presenting opportunities for developing therapeutic strategies for hormone-related disorders and cancers.
| Cat.No | ACP04013 | Target Name | HSD17B11 |
|---|---|---|---|
| Form | Liquid or Lyophilized powder | Expression System | E.coli |
| Expression Range | 20-300aa | Mol Weight | 46.8kDa |
| Protein Length | Full Length of Mature Protein | Purity | Greater than 90% as determined by SDS-PAGE. |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q8NBQ5 |
|---|
Uniprot Id
Q8NBQ5
Target Species
Human
Target Name
HSD17B11
Target Full Name
Estradiol 17-beta-dehydrogenase 11
Target Function
Can convert androstan-3-alpha,17-beta-diol (3-alpha-diol) to androsterone in vitro, suggesting that it may participate in androgen metabolism during steroidogenesis. May act by metabolizing compounds that stimulate steroid synthesis and/or by generating metabolites that inhibit it. Has no activity toward DHEA (dehydroepiandrosterone), or A-dione (4-androste-3,17-dione), and only a slight activity toward testosterone to A-dione. Tumor-associated antigen in cutaneous T-cell lymphoma.
Target Subcellular Location
Endoplasmic reticulum. Lipid droplet.
Target Protein Families
Short-chain dehydrogenases/reductases (SDR) family, 17-beta-HSD 3 subfamily
Target Tissue Specificity
Present at high level in steroidogenic cells such as syncytiotrophoblasts, sebaceous gland, Leydig cells, and granulosa cells of the dominant follicle and corpus luteum. In lung, it is detected in the ciliated epithelium and in acini of adult trachea, in
Target Research Area
Metabolism
Target Synonyms
17 beta HSD 11; 17 beta HSD XI; 17 BETA HSD11; 17 BETA HSDXI ; 17 beta hydroxysteroid dehydrogenase 11; 17 beta hydroxysteroid dehydrogenase type XI; 17 beta hydroxysteroid dehydrogenase XI; 17-beta-HSD 11; 17-beta-HSD XI; 17-beta-hydroxysteroid dehydrogenase 11; 17-beta-hydroxysteroid dehydrogenase XI; 17betaHSD11; 17betaHSDXI; 17bHSD11; CTCL associated antigen HD CL 03; CTCL tumor antigen HD CL 03 ; CTCL-associated antigen HD-CL-03; Cutaneous T cell lymphoma associated antigen HD CL 03; Cutaneous T-cell lymphoma-associated antigen HD-CL-03; Dehydrogenase/reductase SDR family member 8; DHB11_HUMAN; DHRS8; Estradiol 17 beta dehydrogenase 11; Estradiol 17-beta-dehydrogenase 11; Hsd17b11; Hydroxysteroid (17 beta) dehydrogenase 11; PAN1B; Retinal short chain dehydrogenase/reductase 2; Retinal short-chain dehydrogenase/reductase 2; RETSDR2; SDR16C2; SDR2; Short chain dehydrogenase/reductase family 16C member 2; T cell lymphoma associated antigen HD CL 03
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