Recombinant Human Etoposide-induced protein 2.4 homolog (EI24), Truncated

Uniprot Id

O14681

Target Species

Human

Target Name

EI24

Target Full Name

Etoposide-induced protein 2.4 homolog

Target Function

Acts as a negative growth regulator via p53-mediated apoptosis pathway. Regulates formation of degradative autolysosomes during autophagy.

Target Involvement

EI24 is on a chromosomal region frequently deleted in solid tumors, and it is thought to play a role in breast and cervical cancer. Particularly, expression analysis of EI24 in cancerous tissues shows that EI24 loss is associated with tumor invasiveness.

Target Subcellular Location

Nucleus membrane; Multi-pass membrane protein. Cytoplasm. Endoplasmic reticulum membrane; Multi-pass membrane protein.

Target Protein Families

EI24 family

Target Synonyms

EI24; PIG8; Etoposide-induced protein 2.4 homolog; p53-induced gene 8 protein

Target Background

This gene encodes a putative tumor suppressor and has higher expression in p53-expressing cells than in control cells and is an immediate-early induction target of p53-mediated apoptosis. The encoded protein may suppress cell growth by inducing apoptotic cell death through the caspase 9 and mitochondrial pathways. This gene is located on human chromosome 11q24, a region frequently altered in cancers. Alternative splicing results in multiple transcript variants. Pseudogenes of this gene have been defined on chromosomes 1, 3, 7, and 8.