Recombinant Human Eukaryotic translation initiation factor 2A (EIF2A)

Uniprot Id

Q9BY44

Target Species

Human

Target Name

EIF2A

Target Full Name

Eukaryotic translation initiation factor 2A

Target Function

Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl-tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it binds methionyl-tRNAi to 40S subunits in a codon-dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40S subunits in a GTP-dependent manner.

Target Protein Families

WD repeat EIF2A family

Target Tissue Specificity

Widely expressed. Expressed at higher level in pancreas, heart, brain and placenta.

Target Synonyms

65 kDa eukaryotic translation initiation factor 2A; CDA 02; CDA02; EIF 2; EIF 2A; eIF-2A; EIF2; eif2a; EIF2A_HUMAN; Eukaryotic translation initiation factor 2A 65kDa; Eukaryotic translation initiation factor 2A; MST089; MSTP004; MSTP089

Target Background

This gene encodes a eukaryotic translation initiation factor that catalyzes the formation of puromycin-sensitive 80 S preinitiation complexes and the poly(U)-directed synthesis of polyphenylalanine at low concentrations of Mg2+. This gene should not be confused with eIF2-alpha (EIF2S1, Gene ID: 1965), the alpha subunit of the eIF2 translation initiation complex. Although both of these proteins function in binding initiator tRNA to the 40 S ribosomal subunit, the encoded protein does so in a codon-dependent manner, whereas eIF2 complex requires GTP. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms.