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| Cat.No | ACP10385 | Target Name | XPO4 |
|---|---|---|---|
| Target Synonyms | Exp4; Exportin-4; exportin4; FLJ13046; KIAA1721; xpo4; XPO4_HUMAN | Form | Lyophilized powder |
| Expression System | Custom Production. Please inquire and provide the desire expression system. | Protein Length | Partial |
| Purity | >85% (SDS-PAGE) | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q9C0E2 |
|---|
Uniprot Id
Q9C0E2
Target Species
Human
Target Name
XPO4
Target Full Name
Exportin-4
Target Function
Mediates the nuclear export of proteins (cargos) with broad substrate specificity. In the nucleus binds cooperatively to its cargo and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the cargo from the export receptor. XPO4 then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus
Target Subcellular Location
Cytoplasm. Nucleus. Note=Shuttles between the nucleus and the cytoplasm.
Target Protein Families
Exportin family
Target Synonyms
Exp4; Exportin-4; exportin4; FLJ13046; KIAA1721; xpo4; XPO4_HUMAN
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