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Recombinant Human Eyes absent homolog 4 (EYA4)

ACP20488

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Specifications

Cat.No	ACP20488	Target Name	EYA4
Target Synonyms	CMD1J; Deafness	Form	Lyophilized powder
Expression System	Custom Production. Please inquire and provide the desire expression system.	Expression Range	1-639
Protein Length	Full length protein	Purity	>85% (SDS-PAGE)
Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Immunogen Information

Target Species	Human	Uniprot ID	O95677

Background Information

Uniprot Id

O95677
Target Species

Human
Target Name

EYA4
Target Full Name

Protein phosphatase EYA4
Target Function

Tyrosine phosphatase that specifically dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph). 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Promotes efficient DNA repair by dephosphorylating H2AX, promoting the recruitment of DNA repair complexes containing MDC1. Its function as histone phosphatase probably explains its role in transcription regulation during organogenesis. May be involved in development of the eye.
Target Involvement

Deafness, autosomal dominant, 10 (DFNA10); Cardiomyopathy, dilated 1J (CMD1J)
Target Subcellular Location

Cytoplasm. Nucleus.
Target Protein Families

HAD-like hydrolase superfamily, EYA family
Target Tissue Specificity

Highly expressed in heart and skeletal muscle.
Target Synonyms

CMD1J; Deafness, autosomal dominant 10; DFNA 10; DFNA10; dJ78N10.1 (eyes absent (Drosophila) homolog 4); dJ78N10.1 (eyes absent); EYA 4; eya4; EYA4_HUMAN; Eyes absent 4; Eyes absent homolog 4 (Drosophila) ; Eyes absent homolog 4; HGNC:3522; OTTHUMP00000040267

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Recombinant Human Eyes absent homolog 4 (EYA4)

Specifications

Immunogen Information

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