Recombinant Human F-box/WD repeat-containing protein 2 (FBXW2)

Uniprot Id

Q9UKT8

Target Species

Human

Target Name

FBXW2

Target Full Name

F-box/WD repeat-containing protein 2

Target Function

Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.

Target Synonyms

F box and WD 40 domain containing protein 2; F box and WD repeat domain containing 2; F box and WD40 domain protein 2; F box/WD repeat containing protein 2; F-box and WD-40 domain-containing protein 2; F-box/WD repeat-containing protein 2; FBW 2; FBW2; FBXW 2; Fbxw2; FBXW2_HUMAN; Fwd2; Md6; Protein MD6

Target Background

F-box proteins are an expanding family of eukaryotic proteins characterized by an approximately 40 amino acid motif, the F box. Some F-box proteins have been shown to be critical for the ubiquitin-mediated degradation of cellular regulatory proteins. In fact, F-box proteins are one of the four subunits of ubiquitin protein ligases, called SCFs. SCF ligases bring ubiquitin conjugating enzymes to substrates that are specifically recruited by the different F-box proteins. Mammalian F-box proteins are classified into three groups based on the presence of either WD-40 repeats, leucine-rich repeats, or the presence or absence of other protein-protein interacting domains. This gene encodes the second identified member of the F-box gene family and contains multiple WD-40 repeats.