Recombinant Human FCH domain only protein 2 (FCHO2), Truncated

Uniprot Id

Q0JRZ9

Target Species

Human

Target Name

FCHO2

Target Full Name

F-BAR domain only protein 2

Target Function

Functions in an early step of clathrin-mediated endocytosis. Has both a membrane binding/bending activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. Has a lipid-binding activity with a preference for membranes enriched in phosphatidylserine and phosphoinositides (Pi(4,5) biphosphate) like the plasma membrane. Its membrane-bending activity might be important for the subsequent action of clathrin and adaptors in the formation of clathrin-coated vesicles. Involved in adaptor protein complex AP-2-dependent endocytosis of the transferrin receptor, it also functions in the AP-2-independent endocytosis of the LDL receptor.

Target Subcellular Location

Membrane, clathrin-coated pit; Peripheral membrane protein; Cytoplasmic side.

Target Protein Families

FCHO family

Target Synonyms

FCHO2F-BAR domain only protein 2

Target Background

Enables identical protein binding activity. Involved in clathrin coat assembly and clathrin-dependent endocytosis. Located in clathrin-coated pit and clathrin-coated vesicle.