Recombinant Human FERM domain-containing protein 8 (FRMD8)

ACP10397

Number

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Specifications

Cat.No	ACP10397	Target Name	FRMD8
Target Synonyms	FERM domain containing 8; FERM domain containing protein 8; FERM domain-containing protein 8; FKSG44; FLJ32216; FLJ90369; Frmd8; FRMD8_HUMAN; MGC31785	Form	Lyophilized powder
Expression System	Custom Production. Please inquire and provide the desire expression system.	Expression Range	1-464
Protein Length	Full length protein	Purity	>85% (SDS-PAGE)
Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Immunogen Information

Target Species	Human	Uniprot ID	Q9BZ67

Background Information

Uniprot Id

Q9BZ67
Target Species

Human
Target Name

FRMD8
Target Full Name

FERM domain-containing protein 8
Target Function

Promotes the cell surface stability of iRhom1/RHBDF1 and iRhom2/RHBDF2 and prevents their degradation via the endolysosomal pathway. By acting on iRhoms, involved in ADAM17-mediated shedding of TNF, amphiregulin/AREG, HBEGF and TGFA from the cell surface. Negatively regulates Wnt signaling, possibly by antagonizing the recruitment of AXIN1 to LRP6.
Target Subcellular Location

Cytoplasm, cytosol. Cell membrane.
Target Tissue Specificity

Widely expressed, with high expression in heart and spleen.
Target Synonyms

FERM domain containing 8; FERM domain containing protein 8; FERM domain-containing protein 8; FKSG44; FLJ32216; FLJ90369; Frmd8; FRMD8_HUMAN; MGC31785

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Recombinant Human FERM domain-containing protein 8 (FRMD8)

Specifications

Immunogen Information

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