Recombinant Human Fibroblast growth factor 19 (FGF19)

Uniprot Id

O95750

Target Species

Human

Target Name

FGF19

Target Full Name

Fibroblast growth factor 19

Target Function

Involved in the suppression of bile acid biosynthesis through down-regulation of CYP7A1 expression, following positive regulation of the JNK and ERK1/2 cascades. Stimulates glucose uptake in adipocytes. Activity requires the presence of KLB and FGFR4.

Target Subcellular Location

Secreted.

Target Protein Families

Heparin-binding growth factors family

Target Tissue Specificity

Expressed in fetal brain, cartilage, retina, and adult gall bladder.

Target Research Area

Signal Transduction

Target Synonyms

FGF 19; FGF-19; FGF15; FGF19; FGF19_HUMAN; Fibroblast growth factor 15; Fibroblast growth factor 19

Target Background

The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes including embryonic development cell growth, morphogenesis, tissue repair, tumor growth and invasion. This growth factor is a high affinity, heparin dependent ligand for FGFR4. Expression of this gene was detected only in fetal but not adult brain tissue. Synergistic interaction of the chick homolog and Wnt-8c has been shown to be required for initiation of inner ear development.