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Recombinant Human Fibronectin type III domain-containing protein 4 (FNDC4), Truncated

ACP11526

Number
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High Purity LevelsPrecision and ReliabilityCustomization Options

Specifications


Cat.No ACP11526 Target NameFNDC4
FormLyophilized powderExpression SystemCustom Production. Please inquire and provide the desire expression system.
Protein LengthPartialPurity>85% (SDS-PAGE)
Storage Buffer5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Immunogen Information


Target SpeciesHumanUniprot IDQ9H6D8
Background Information
  • Uniprot Id

    Q9H6D8

  • Target Species

    Human

  • Target Name

    FNDC4

  • Target Full Name

    Fibronectin type III domain-containing protein 4

  • Target Function

    Acts as an anti-inflammatory factor in the intestine and colon. Binds to and acts on macrophages to downregulate pro-inflammatory gene expression. Affects key macrophage functions, including phagocytosis, by downregulating many key pathways for macrophage activation, partly via by STAT3 activation and signaling. May be required to dampen the immunological response in colitis.

  • Target Subcellular Location

    Membrane; Single-pass type I membrane protein. Secreted.

  • Target Tissue Specificity

    Up-regulated in colon cells of patients with inflammatory bowel disease (IBD).

  • Target Synonyms

    Fibronectin type III domain containing 4; Fibronectin type III domain containing protein 4; Fibronectin type III domain-containing protein 4; Fibronectin type III repeat containing protein 1; Fibronectin type III repeat-containing protein 1; FLJ22362; FNDC 4; FNDC4; FNDC4_HUMAN; FRCP 1; FRCP1

  • Target Background

    Involved in response to transforming growth factor beta. Predicted to be located in endoplasmic reticulum and extracellular space. Predicted to be active in extracellular region and plasma membrane.

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