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The production of this Recombinant Human FOXP3 protein required the insertion of a DNA fragment (FOXP3, 1-260aa) into an expression vector and the transferral of this vector into E.coli cells (the step of transformation). The cells were then cultured and induced to express the FOXP3 protein. This recombinant protein was fused with N-terminal 6xHis tag. Its purity is 90%+ determined by SDS-PAGE.FOXP3 (also called IPEX) is a gene encoding a protein called forkhead box protein P3 (FOXP3) (also known as scurfin) in human. The protein encoded by this gene can be cleaved into two chains, including forkhead box protein P3, C-terminally processed and forkhead box protein P3 41 kDa form. The FOXP3 protein can bind to specific regions of DNA and function as a master regulator of the regulatory pathway in regulating the immune system response. The FOXP3 protein is found primarily in the thymus (an immune system gland), where these regulatory T cells are produced.
The production of this Recombinant Human FOXP3 protein required the insertion of a DNA fragment (FOXP3, 1-260aa) into an expression vector and the transferral of this vector into E.coli cells (the step of transformation). The cells were then cultured and induced to express the FOXP3 protein. This recombinant protein was fused with N-terminal 6xHis tag. Its purity is 90%+ determined by SDS-PAGE.FOXP3 (also called IPEX) is a gene encoding a protein called forkhead box protein P3 (FOXP3) (also known as scurfin) in human. The protein encoded by this gene can be cleaved into two chains, including forkhead box protein P3, C-terminally processed and forkhead box protein P3 41 kDa form. The FOXP3 protein can bind to specific regions of DNA and function as a master regulator of the regulatory pathway in regulating the immune system response. The FOXP3 protein is found primarily in the thymus (an immune system gland), where these regulatory T cells are produced.
| Cat.No | ACP02276 | Target Name | FOXP3 |
|---|---|---|---|
| Form | Liquid or Lyophilized powder | Expression System | E.coli |
| Expression Range | 1-260aa | Mol Weight | 31.7kDa |
| Protein Length | Partial | Purity | Greater than 90% as determined by SDS-PAGE. |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q9BZS1 |
|---|
Uniprot Id
Q9BZS1
Target Species
Human
Target Name
FOXP3
Target Full Name
Forkhead box protein P3
Target Function
Transcriptional regulator which is crucial for the development and inhibitory function of regulatory T-cells (Treg). Plays an essential role in maintaining homeostasis of the immune system by allowing the acquisition of full suppressive function and stability of the Treg lineage, and by directly modulating the expansion and function of conventional T-cells. Can act either as a transcriptional repressor or a transcriptional activator depending on its interactions with other transcription factors, histone acetylases and deacetylases. The suppressive activity of Treg involves the coordinate activation of many genes, including CTLA4 and TNFRSF18 by FOXP3 along with repression of genes encoding cytokines such as interleukin-2 (IL2) and interferon-gamma (IFNG). Inhibits cytokine production and T-cell effector function by repressing the activity of two key transcription factors, RELA and NFATC2. Mediates transcriptional repression of IL2 via its association with histone acetylase KAT5 and histone deacetylase HDAC7. Can activate the expression of TNFRSF18, IL2RA and CTLA4 and repress the expression of IL2 and IFNG via its association with transcription factor RUNX1. Inhibits the differentiation of IL17 producing helper T-cells (Th17) by antagonizing RORC function, leading to down-regulation of IL17 expression, favoring Treg development. Inhibits the transcriptional activator activity of RORA. Can repress the expression of IL2 and IFNG via its association with transcription factor IKZF4.
Target Involvement
Immunodeficiency polyendocrinopathy, enteropathy, X-linked syndrome (IPEX)
Target Subcellular Location
Nucleus. Cytoplasm.
Target Research Area
Transcription
Target Synonyms
AIID; DIETER; Forkhead box P3; Forkhead box protein P3; FOXP3; FOXP3_HUMAN; FOXP3delta7; Immune dysregulation polyendocrinopathy enteropathy X linked; Immunodeficiency polyendocrinopathy enteropathy X linked; IPEX; JM2; MGC141961; MGC141963; OTTHUMP00000025832; OTTHUMP00000025833; OTTHUMP00000226737; PIDX; Scurfin; XPID
Target Background
The protein encoded by this gene is a member of the forkhead/winged-helix family of transcriptional regulators. Defects in this gene are the cause of immunodeficiency polyendocrinopathy, enteropathy, X-linked syndrome (IPEX), also known as X-linked autoimmunity-immunodeficiency syndrome. Alternatively spliced transcript variants encoding different isoforms have been identified.
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