Recombinant Human G-protein-signaling modulator 1 (GPSM1)

Uniprot Id

Q86YR5

Target Species

Human

Target Name

GPSM1

Target Full Name

G-protein-signaling modulator 1

Target Function

Guanine nucleotide dissociation inhibitor (GDI) which functions as a receptor-independent activator of heterotrimeric G-protein signaling. Keeps G(i/o) alpha subunit in its GDP-bound form thus uncoupling heterotrimeric G-proteins signaling from G protein-coupled receptors. Controls spindle orientation and asymmetric cell fate of cerebral cortical progenitors. May also be involved in macroautophagy in intestinal cells. May play a role in drug addiction.

Target Subcellular Location

Cytoplasm, cytosol. Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Cell membrane; Peripheral membrane protein; Cytoplasmic side.

Target Protein Families

GPSM family

Target Tissue Specificity

Expressed in intestinal cells.

Target Synonyms

Activator of G-protein signaling 3; AGS3; AGS3 homolog ; C10a; G protein signaling modulator 1 (AGS3 like; C. elegans) ; G-protein-signaling modulator 1; GPSM1; GPSM1_HUMAN

Target Background

G-protein signaling modulators (GPSMs) play diverse functional roles through their interaction with G-protein subunits. This gene encodes a receptor-independent activator of G protein signaling, which is one of several factors that influence the basal activity of G-protein signaling systems. The protein contains seven tetratricopeptide repeats in its N-terminal half and four G-protein regulatory (GPR) motifs in its C-terminal half. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene.