Recombinant Human G-protein-signaling modulator 2 (GPSM2)

Cat.No	ACP24605	Target Name	GPSM2
Form	Lyophilized powder	Expression System	Custom Production. Please inquire and provide the desire expression system.
Expression Range	1-684	Protein Length	Full length protein
Purity	>85% (SDS-PAGE)	Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Cat.No

ACP24605

Target Name

GPSM2

Form

Lyophilized powder

Expression System

Custom Production. Please inquire and provide the desire expression system.

Expression Range

1-684

Protein Length

Full length protein

Purity

>85% (SDS-PAGE)

Storage Buffer

5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Target Species	Human	Uniprot ID	P81274

Background Information

Uniprot Id

P81274
Target Species

Human
Target Name

GPSM2
Target Full Name

G-protein-signaling modulator 2
Target Function

Plays an important role in mitotic spindle pole organization via its interaction with NUMA1. Required for cortical dynein-dynactin complex recruitment during metaphase. Plays a role in metaphase spindle orientation. Plays also an important role in asymmetric cell divisions. Has guanine nucleotide dissociation inhibitor (GDI) activity towards G(i) alpha proteins, such as GNAI1 and GNAI3, and thereby regulates their activity.
Target Involvement

Chudley-McCullough syndrome (CMCS)
Target Subcellular Location

Cytoplasm. Cytoplasm, cell cortex. Cytoplasm, cytoskeleton, spindle pole. Lateral cell membrane.
Target Protein Families

GPSM family
Target Tissue Specificity

Ubiquitously expressed.
Target Synonyms

DFNB82; G protein signalling modulator 2 (AGS3 like C. elegans); G protein signalling modulator 2; G-protein-signaling modulator 2; Gpsm2; GPSM2_HUMAN; HGNC:29501; LGN; LGN protein; Mosaic protein LGN; Pins
Target Background

The protein encoded by this gene belongs to a family of proteins that modulate activation of G proteins, which transduce extracellular signals received by cell surface receptors into integrated cellular responses. The N-terminal half of this protein contains 10 copies of leu-gly-asn (LGN) repeat, and the C-terminal half contains 4 GoLoco motifs, which are involved in guanine nucleotide exchange. This protein may play a role in neuroblast division and in the development of normal hearing. Mutations in this gene are associated with autosomal recessive nonsyndromic deafness (DFNB82). Alternative splicing results in multiple transcript variants.

Recombinant Human G-protein-signaling modulator 2 (GPSM2)

Specifications

Immunogen Information

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