Recombinant Human G-rich sequence factor 1 (GRSF1)

Uniprot Id

Q12849

Target Species

Human

Target Name

GRSF1

Target Full Name

G-rich sequence factor 1

Target Function

Regulator of post-transcriptional mitochondrial gene expression, required for assembly of the mitochondrial ribosome and for recruitment of mRNA and lncRNA. Binds RNAs containing the 14 base G-rich element. Preferentially binds RNAs transcribed from three contiguous genes on the light strand of mtDNA, the ND6 mRNA, and the long non-coding RNAs for MT-CYB and MT-ND5, each of which contains multiple consensus binding sequences. Involved in the degradosome-mediated decay of non-coding mitochondrial transcripts (MT-ncRNA) and tRNA-like molecules. Acts by unwinding G-quadruplex RNA structures in MT-ncRNA, thus facilitating their degradation by the degradosome. G-quadruplexes (G4) are non-canonical 4 stranded structures formed by transcripts from the light strand of mtDNA

Target Subcellular Location

[Isoform 1]: Mitochondrion matrix.; [Isoform 2]: Cytoplasm.

Target Synonyms

G rich RNA sequence binding factor 1; G rich sequence binding factor 1; G-rich sequence factor 1; GRSF-1; GRSF1; GRSF1_HUMAN