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Amino acids 17-242 form the expressed segment for recombinant Human GABRP. The theoretical molecular weight of the GABRP protein is 28.9 kDa. This protein is generated in a e.coli-based system. The GABRP gene fragment has been modified by fusing the N-terminal 6xHis tag, providing convenience in detecting and purifying the recombinant GABRP protein during the following stages.Gamma-aminobutyric acid receptor subunit pi (GABRP) is an integral component of the GABA-A receptor family, integral for mediating inhibitory neurotransmission in the central nervous system. As a subunit of the GABA-A receptor, GABRP contributes to the formation of functional receptor complexes, playing a pivotal role in regulating neuronal excitability. Beyond its fundamental involvement in neurotransmission, GABRP has been associated with various physiological and pathological processes, including anxiety, epilepsy, and certain neurodevelopmental disorders.
Amino acids 17-242 form the expressed segment for recombinant Human GABRP. The theoretical molecular weight of the GABRP protein is 28.9 kDa. This protein is generated in a e.coli-based system. The GABRP gene fragment has been modified by fusing the N-terminal 6xHis tag, providing convenience in detecting and purifying the recombinant GABRP protein during the following stages.Gamma-aminobutyric acid receptor subunit pi (GABRP) is an integral component of the GABA-A receptor family, integral for mediating inhibitory neurotransmission in the central nervous system. As a subunit of the GABA-A receptor, GABRP contributes to the formation of functional receptor complexes, playing a pivotal role in regulating neuronal excitability. Beyond its fundamental involvement in neurotransmission, GABRP has been associated with various physiological and pathological processes, including anxiety, epilepsy, and certain neurodevelopmental disorders.
| Cat.No | ACP01913 | Target Name | GABRP |
|---|---|---|---|
| Target Synonyms | GABA(A) receptor subunit pi | Form | Liquid or Lyophilized powder |
| Expression System | E.coli | Expression Range | 17-242aa |
| Mol Weight | 28.9 kDa | Protein Length | Partial |
| Purity | Greater than 85% as determined by SDS-PAGE. | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | O00591 |
|---|
Uniprot Id
O00591
Target Species
Human
Target Name
GABRP
Target Full Name
Gamma-aminobutyric acid receptor subunit pi
Target Function
GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. In the uterus, the function of the receptor appears to be related to tissue contractility. The binding of this pI subunit with other GABA(A) receptor subunits alters the sensitivity of recombinant receptors to modulatory agents such as pregnanolone.
Target Subcellular Location
Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
Target Protein Families
Ligand-gated ion channel (TC 1.A.9) family, Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily, GABRP sub-subfamily
Target Tissue Specificity
Most abundant in the uterus, also expressed in lung, thymus and prostate.
Target Research Area
Others
Target Synonyms
GABA(A) receptor subunit pi; GABRP; Gamma aminobutyric acid (GABA) A receptor pi; Gamma aminobutyric acid A receptor pi; Gamma aminobutyric acid receptor pi subunit; Gamma aminobutyric acid receptor subunit pi; Gamma-aminobutyric acid receptor subunit pi; GBRP_HUMAN; MGC126386; MGC126387
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