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The region for expressing recombinant Human GFRAL contains amino acids 19-351. This GFRAL protein is theoretically predicted to have a molecular weight of 53.8 kDa. Expression of this GFRAL protein is conducted in e.coli. Fusion of the N-terminal 6xHis-SUMO tag into the GFRAL encoding gene fragment was conducted, allowing for easier detection and purification of the GFRAL protein in subsequent stages.Human GDNF family receptor alpha-like (GFRAL) is a receptor associated with energy homeostasis. GFRAL mainly functions to mediate the effects of the GDNF family ligands on appetite regulation and body weight. Investigating GFRAL provides insights into neuroendocrine signaling, metabolic disorders, and cancer-related wasting, offering potential applications in developing interventions for obesity, metabolic diseases, and cancer-associated cachexia. In metabolic research, GFRAL is crucial for understanding mechanisms underlying obesity and metabolic disorders. Targeting GFRAL presents a potential avenue for developing anti-obesity therapeutics. Additionally, GFRAL's role in cancer cachexia implicates it in cancer research.
The region for expressing recombinant Human GFRAL contains amino acids 19-351. This GFRAL protein is theoretically predicted to have a molecular weight of 53.8 kDa. Expression of this GFRAL protein is conducted in e.coli. Fusion of the N-terminal 6xHis-SUMO tag into the GFRAL encoding gene fragment was conducted, allowing for easier detection and purification of the GFRAL protein in subsequent stages.Human GDNF family receptor alpha-like (GFRAL) is a receptor associated with energy homeostasis. GFRAL mainly functions to mediate the effects of the GDNF family ligands on appetite regulation and body weight. Investigating GFRAL provides insights into neuroendocrine signaling, metabolic disorders, and cancer-related wasting, offering potential applications in developing interventions for obesity, metabolic diseases, and cancer-associated cachexia. In metabolic research, GFRAL is crucial for understanding mechanisms underlying obesity and metabolic disorders. Targeting GFRAL presents a potential avenue for developing anti-obesity therapeutics. Additionally, GFRAL’s role in cancer cachexia implicates it in cancer research.
| Cat.No | ACP02447 | Target Name | C6orf144 |
|---|---|---|---|
| Target Synonyms | bA360D14.1; C6orf144; GDNF family receptor alpha-like; Gfral; GFRAL_HUMAN; GRAL; IVFI9356; UNQ9356; UNQ9356/PRO34128 | Form | Liquid or Lyophilized powder |
| Expression System | E.coli | Expression Range | 19-351aa |
| Mol Weight | 53.8kDa | Protein Length | Extracellular Domain |
| Purity | Greater than 90% as determined by SDS-PAGE. | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q6UXV0 |
|---|
Uniprot Id
Q6UXV0
Target Species
Human
Target Name
GFRAL
Target Full Name
GDNF family receptor alpha-like
Target Function
Brainstem-restricted receptor for GDF15 which regulates food intake, energy expenditure and body weight in response to metabolic and toxin-induced stresses. Upon interaction with its ligand, GDF15, interacts with RET and induces cellular signaling through activation of MAPK- and AKT- signaling pathways.
Target Subcellular Location
Cell membrane; Single-pass membrane protein; Extracellular side.
Target Protein Families
GDNFR family
Target Tissue Specificity
Expressed in the brainstem, restricted to cells in the area postrema and the immediately adjacent region of the nucleus tractus solitarius (at protein level). Detected at low levels in testis and adipose tissue.
Target Research Area
Cell Biology
Target Synonyms
bA360D14.1; C6orf144; GDNF family receptor alpha-like; Gfral; GFRAL_HUMAN; GRAL; IVFI9356; UNQ9356; UNQ9356/PRO34128
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