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This Human GGPS1 recombinant protein was produced in E.coli, where the gene sequence encoding Human GGPS1 (1-300aa) was expressed with the N-terminal 6xHis-SUMO tag. The purity of this GGPS1 protein was greater than 90% by SDS-PAGE.Geranylgeranyl pyrophosphate synthase (GGPS1) is a key enzyme in plant terpenoid biosynthesis. The enzyme catalyzes the synthesis of geranylgeranyl pyrophosphate (GGPP), which is a precursor to several holoterpenoids (carotenoids, kaurene, diterpenes) and meroterpenoids (side-chain of chlorophylls, tocopherols, plastoquinones, phylloquinones). The study identified a cDNA for the plastid-located GGPS1 from Capsicum annuum and showed a correlative increase in enzyme activity and transcript level during fruit ripening. The cloned cDNA codes for a high molecular weight precursor of 369 amino acids which contains a transit peptide of approximately 60 amino acids. In-situ immunolocalization experiments have demonstrated that geranylgeranyl pyrophosphate synthase is located exclusively in the plastids. Reference:Kuntz M, R?mer S, Suire C, Hugueney P, Weil JH, Schantz R, Camara B. Identification of a cDNA for the plastid-located geranylgeranyl pyrophosphate synthase from Capsicum annuum: correlative increase in enzyme activity and transcript level during fruit ripening. Plant J. 1992 Jan;2(1):25-34.
This Human GGPS1 recombinant protein was produced in E.coli, where the gene sequence encoding Human GGPS1 (1-300aa) was expressed with the N-terminal 6xHis-SUMO tag. The purity of this GGPS1 protein was greater than 90% by SDS-PAGE.Geranylgeranyl pyrophosphate synthase (GGPS1) is a key enzyme in plant terpenoid biosynthesis. The enzyme catalyzes the synthesis of geranylgeranyl pyrophosphate (GGPP), which is a precursor to several holoterpenoids (carotenoids, kaurene, diterpenes) and meroterpenoids (side-chain of chlorophylls, tocopherols, plastoquinones, phylloquinones). The study identified a cDNA for the plastid-located GGPS1 from Capsicum annuum and showed a correlative increase in enzyme activity and transcript level during fruit ripening. The cloned cDNA codes for a high molecular weight precursor of 369 amino acids which contains a transit peptide of approximately 60 amino acids. In-situ immunolocalization experiments have demonstrated that geranylgeranyl pyrophosphate synthase is located exclusively in the plastids.
Reference:Kuntz M, R?mer S, Suire C, Hugueney P, Weil JH, Schantz R, Camara B. Identification of a cDNA for the plastid-located geranylgeranyl pyrophosphate synthase from Capsicum annuum: correlative increase in enzyme activity and transcript level during fruit ripening. Plant J. 1992 Jan;2(1):25-34.
| Cat.No | ACP03972 | Target Name | GGPS1 |
|---|---|---|---|
| Form | Liquid or Lyophilized powder | Expression System | E.coli |
| Expression Range | 1-300aa | Mol Weight | 50.9kDa |
| Protein Length | Full length | Purity | Greater than 90% as determined by SDS-PAGE. |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | O95749 |
|---|
Uniprot Id
O95749
Target Species
Human
Target Name
GGPS1
Target Full Name
Geranylgeranyl pyrophosphate synthase
Target Function
Catalyzes the trans-addition of the three molecules of IPP onto DMAPP to form geranylgeranyl pyrophosphate, an important precursor of carotenoids and geranylated proteins.
Target Subcellular Location
Cytoplasm.
Target Protein Families
FPP/GGPP synthase family
Target Tissue Specificity
Abundantly expressed in testis. Found in other tissues to a lower extent.
Target Research Area
Cancer
Target Synonyms
(2E; 6E)-farnesyl diphosphate synthase; Dimethylallyltranstransferase; Farnesyl diphosphate synthase; Farnesyltranstransferase; Geranylgeranyl diphosphate synthase 1; Geranylgeranyl diphosphate synthase; Geranylgeranyl pyrophosphate synthase; Geranylgeranyl pyrophosphate synthetase; Geranyltranstransferase; GGPP synthase; GGPP synthetase; GGPPS; GGPPS_HUMAN; GGPPS1; GGPPSase; GGPS1; OTTHUMP00000036073; OTTHUMP00000216161; OTTHUMP00000216163; OTTHUMP00000216164
Target Background
This gene is a member of the prenyltransferase family and encodes a protein with geranylgeranyl diphosphate (GGPP) synthase activity. The enzyme catalyzes the synthesis of GGPP from farnesyl diphosphate and isopentenyl diphosphate. GGPP is an important molecule responsible for the C20-prenylation of proteins and for the regulation of a nuclear hormone receptor. Alternate transcriptional splice variants, both protein-coding and non-protein-coding, have been found for this gene.
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