Recombinant Human Glutamate receptor-interacting protein 1 (GRIP1), Truncated

Uniprot Id

Q9Y3R0

Target Species

Human

Target Name

GRIP1

Target Full Name

Glutamate receptor-interacting protein 1

Target Function

May play a role as a localized scaffold for the assembly of a multiprotein signaling complex and as mediator of the trafficking of its binding partners at specific subcellular location in neurons. Through complex formation with NSG1, GRIA2 and STX12 controls the intracellular fate of AMPAR and the endosomal sorting of the GRIA2 subunit toward recycling and membrane targeting.

Target Involvement

Fraser syndrome 3 (FRASRS3)

Target Subcellular Location

Cytoplasmic vesicle. Perikaryon. Cell projection, dendrite. Cytoplasm. Endomembrane system; Peripheral membrane protein. Cell junction, synapse, postsynaptic cell membrane. Cell junction, synapse, postsynaptic density. Endoplasmic reticulum membrane; Peripheral membrane protein.

Target Synonyms

as GRIP; Glutamate receptor-interacting protein 1; GRIP-1; Grip1; GRIP1_HUMAN

Target Background

This gene encodes a member of the glutamate receptor interacting protein family. The encoded scaffold protein binds to and mediates the trafficking and membrane organization of a number of transmembrane proteins. Alternatively spliced transcript variants encoding different isoforms have been described.