Recombinant Human Glutathione S-transferase theta-2B (GSTT2B)

Uniprot Id

P0CG30

Target Species

Human

Target Name

GSTT2B

Target Full Name

Glutathione S-transferase theta-2B

Target Function

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Has a sulfatase activity.

Target Subcellular Location

Cytoplasm.

Target Protein Families

GST superfamily, Theta family

Target Tissue Specificity

Expressed at low levels in liver. In lung, expressed at low levels in ciliated bronchiolar cells, alveolar macrophages and alveolar type II cells.

Target Synonyms

AI266894; EC 2.5.1.18; Glutathione S transferase 12; Glutathione S transferase Yrs Yrs; Glutathione S-transferase theta-2; Glutathione S-transferase theta-2B; GST 12 12; GST class theta 2; GST class-theta-2; GST T2; GSTT 2; GSTT2; GSTT2 protein; GSTT2_HUMAN; GSTT2B; GSTT2P; MGC182032; mGSTT2; OTTHUMP00000198491; OTTHUMP00000198492; Yrs

Target Background

The protein encoded by this gene, glutathione S-transferase (GST) theta 2B (GSTT2B), is a member of a superfamily of proteins that catalyze the conjugation of reduced glutathione to a variety of electrophilic and hydrophobic compounds. Human GSTs can be divided into five main classes: alpha, mu, pi, theta, and zeta. The theta class includes GSTT1, GSTT2, and GSTT2B. GSTT2 and GSTT2B are nearly identical to each other, and share 55% amino acid identity with GSTT1. All three genes may play a role in human carcinogenesis. The GSTT2B gene is a pseudogene in some populations.