Recombinant Human GPI ethanolamine phosphate transferase 3 (PIGO), Truncated

Uniprot Id

Q8TEQ8

Target Species

Human

Target Name

PIGO

Target Full Name

GPI ethanolamine phosphate transferase 3

Target Function

Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the GPI third mannose which links the GPI-anchor to the C-terminus of the proteins by an amide bond.

Target Involvement

Hyperphosphatasia with mental retardation syndrome 2 (HPMRS2)

Target Subcellular Location

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Target Protein Families

PIGG/PIGN/PIGO family, PIGO subfamily

Target Synonyms

PIGO; UNQ632/PRO1249; GPI ethanolamine phosphate transferase 3; EC 2.-.-.-; Phosphatidylinositol-glycan biosynthesis class O protein; PIG-O

Target Background

This gene encodes a protein that is involved in glycosylphosphatidylinositol (GPI)-anchor biosynthesis. The GPI-anchor is a glycolipid which contains three mannose molecules in its core backbone. The GPI-anchor is found on many blood cells and serves to anchor proteins to the cell surface. This protein is involved in the transfer of ethanolaminephosphate (EtNP) to the third mannose in GPI. At least three alternatively spliced transcripts encoding two distinct isoforms have been found for this gene.