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| Cat.No | ACP18669 | Target Name | GRB14 |
|---|---|---|---|
| Target Synonyms | GRB14Growth factor receptor-bound protein 14; GRB14 adapter protein | Form | Lyophilized powder |
| Expression System | Custom Production. Please inquire and provide the desire expression system. | Expression Range | 2-540 |
| Protein Length | Full Length of Mature Protein | Purity | >85% (SDS-PAGE) |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q14449 |
|---|
Uniprot Id
Q14449
Target Species
Human
Target Name
GRB14
Target Full Name
Growth factor receptor-bound protein 14
Target Function
Adapter protein which modulates coupling of cell surface receptor kinases with specific signaling pathways. Binds to, and suppresses signals from, the activated insulin receptor (INSR). Potent inhibitor of insulin-stimulated MAPK3 phosphorylation. Plays a critical role regulating PDPK1 membrane translocation in response to insulin stimulation and serves as an adapter protein to recruit PDPK1 to activated insulin receptor, thus promoting PKB/AKT1 phosphorylation and transduction of the insulin signal.
Target Subcellular Location
Cytoplasm. Endosome membrane; Peripheral membrane protein.
Target Protein Families
GRB7/10/14 family
Target Tissue Specificity
Expressed at high levels in the liver, kidney, pancreas, testis, ovary, heart and skeletal muscle.
Target Synonyms
GRB14Growth factor receptor-bound protein 14; GRB14 adapter protein
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