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| Cat.No | ACP11136 | Target Name | GSKIP |
|---|---|---|---|
| Target Synonyms | C14ORF129; Chromosome 14 open reading frame 129 ; GSK3-beta interaction protein; GSK3beta interaction protein; GSKIP; GSKIP_HUMAN; MGC4945; UPF0279 | Form | Lyophilized powder |
| Expression System | Custom Production. Please inquire and provide the desire expression system. | Expression Range | 1-139 |
| Protein Length | Full length protein | Purity | >85% (SDS-PAGE) |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q9P0R6 |
|---|
Uniprot Id
Q9P0R6
Target Species
Human
Target Name
GSKIP
Target Full Name
GSK3B-interacting protein
Target Function
A-kinase anchoring protein for GSK3B and PKA that regulates or facilitates their kinase activity towards their targets. The ternary complex enhances Wnt-induced signaling by facilitating the GSK3B- and PKA-induced phosphorylation of beta-catenin leading to beta-catenin degradation and stabilization respectively. Upon cAMP activation, the ternary complex contributes to neuroprotection against oxidative stress-induced apoptosis by facilitating the PKA-induced phosphorylation of DML1 and PKA-induced inactivation of GSK3B. During neurite outgrowth promotes neuron proliferation; while increases beta-catenin-induced transcriptional activity through GSK3B kinase activity inhibition, reduces N-cadherin level to promote cell cycle progression
Target Subcellular Location
Cytoplasm. Nucleus.
Target Protein Families
GSKIP family
Target Tissue Specificity
Detected in heart, brain, placenta, liver, skeletal muscle, kidney, testis, lung and pancreas.
Target Synonyms
C14ORF129; Chromosome 14 open reading frame 129 ; GSK3-beta interaction protein; GSK3beta interaction protein; GSKIP; GSKIP_HUMAN; MGC4945; UPF0279
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