Recombinant Human Guanine nucleotide-binding protein G (I)/G (S)/G (O) subunit gamma-7 (GNG7)

Uniprot Id

O60262

Target Species

Human

Target Name

GNG7

Target Full Name

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7

Target Function

Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. Plays a role in the regulation of adenylyl cyclase signaling in certain regions of the brain. Plays a role in the formation or stabilzation of a G protein heterotrimer (G(olf) subunit alpha-beta-gamma-7) that is required for adenylyl cyclase activity in the striatum.

Target Subcellular Location

Cell membrane; Lipid-anchor; Cytoplasmic side.

Target Protein Families

G protein gamma family

Target Tissue Specificity

Expressed in a variety of tissues. Down-regulated in pancreatic and esophageal cancer.

Target Synonyms

GNG7; GNGT7; Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7

Target Background

Predicted to enable G-protein beta-subunit binding activity. Predicted to be involved in G protein-coupled receptor signaling pathway and regulation of adenylate cyclase activity. Predicted to act upstream of or within behavioral fear response; locomotory behavior; and receptor guanylyl cyclase signaling pathway. Located in extracellular exosome.