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Recombinant Human Guanine nucleotide-binding protein G (o) subunit alpha (GNAO1)

ACP22154

Number
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High Purity LevelsPrecision and ReliabilityCustomization Options

Specifications


Cat.No ACP22154 Target NameGNAO1
FormLyophilized powderExpression SystemCustom Production. Please inquire and provide the desire expression system.
Expression Range2-354Protein LengthFull Length of Mature Protein
Purity>85% (SDS-PAGE)Storage Buffer5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Immunogen Information


Target SpeciesHumanUniprot IDP09471
Background Information
  • Uniprot Id

    P09471

  • Target Species

    Human

  • Target Name

    GNAO1

  • Target Full Name

    Guanine nucleotide-binding protein G(o) subunit alpha

  • Target Function

    Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(o) protein function is not clear. Stimulated by RGS14.

  • Target Involvement

    Epileptic encephalopathy, early infantile, 17 (EIEE17); Neurodevelopmental disorder with involuntary movements (NEDIM)

  • Target Subcellular Location

    Cell membrane. Membrane; Lipid-anchor.

  • Target Protein Families

    G-alpha family, G(i/o/t/z) subfamily

  • Target Synonyms

    DKFZp686O0962; G alpha o; G protein alpha 0; Galphao; GNAO 1; GNAO; GNAO_HUMAN; GNAO1; Go alpha; Guanine nucleotide binding protein (G protein) alpha activating activity polypeptide O; Guanine nucleotide binding protein alpha activating polypeptide ; Guanine nucleotide binding protein G(o) subunit alpha; Guanine nucleotide-binding protein G(o) subunit alpha

  • Target Background

    The protein encoded by this gene represents the alpha subunit of the Go heterotrimeric G-protein signal-transducing complex. Defects in this gene are a cause of early-onset epileptic encephalopathy. Two transcript variants encoding different isoforms have been found for this gene.

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