Recombinant Human Guanine nucleotide-binding protein G(q) subunit alpha (GNAQ)

Uniprot Id

P50148

Target Species

Human

Target Name

GNAQ

Target Full Name

Guanine nucleotide-binding protein G(q) subunit alpha

Target Function

Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Regulates B-cell selection and survival and is required to prevent B-cell-dependent autoimmunity. Regulates chemotaxis of BM-derived neutrophils and dendritic cells (in vitro). Transduces FFAR4 signaling in response to long-chain fatty acids (LCFAs).

Target Involvement

Capillary malformations, congenital (CMC); Sturge-Weber syndrome (SWS)

Target Subcellular Location

Cell membrane; Lipid-anchor. Golgi apparatus. Nucleus. Nucleus membrane.

Target Protein Families

G-alpha family, G(q) subfamily

Target Tissue Specificity

Predominantly expressed in ovary, prostate, testis and colon. Down-regulated in the peripheral blood lymphocytes (PBLs) of rheumatoid arthritis patients (at protein level).

Target Research Area

Cardiovascular

Target Synonyms

CMC1; G alpha Q; G protein alpha Q; G protein subunit alpha q; G-ALPHA-q; GAQ; GNAQ; GNAQ_HUMAN; guanine nucleotide binding protein (G protein); q polypeptide; Guanine nucleotide binding protein alpha q; guanine nucleotide binding protein G protein q polypeptide; Guanine nucleotide binding protein G q subunit alpha; Guanine nucleotide-binding protein alpha-q; Guanine nucleotide-binding protein G(q) subunit alpha; SWS

Target Background

This locus encodes a guanine nucleotide-binding protein. The encoded protein, an alpha subunit in the Gq class, couples a seven-transmembrane domain receptor to activation of phospolipase C-beta. Mutations at this locus have been associated with problems in platelet activation and aggregation. A related pseudogene exists on chromosome 2.