Recombinant Human Guanine nucleotide-binding protein G (s) subunit alpha isoforms short

Uniprot Id

P63092

Target Species

Human

Target Name

GNAS

Target Full Name

Guanine nucleotide-binding protein G(s) subunit alpha isoforms short

Target Function

Guanine nucleotide-binding proteins (G proteins) function as transducers in numerous signaling pathways controlled by G protein-coupled receptors (GPCRs). Signaling involves the activation of adenylyl cyclases, resulting in increased levels of the signaling molecule cAMP. GNAS functions downstream of several GPCRs, including beta-adrenergic receptors. Stimulates the Ras signaling pathway via RAPGEF2.

Target Involvement

Albright hereditary osteodystrophy (AHO); Pseudohypoparathyroidism 1A (PHP1A); McCune-Albright syndrome (MAS); Progressive osseous heteroplasia (POH); ACTH-independent macronodular adrenal hyperplasia 1 (AIMAH1); Pseudohypoparathyroidism 1B (PHP1B); GNAS hyperfunction (GNASHYP); Pseudohypoparathyroidism 1C (PHP1C)

Target Subcellular Location

Cell membrane; Lipid-anchor.

Target Protein Families

G-alpha family, G(s) subfamily

Target Research Area

Signal Transduction

Target Synonyms

Adenylate cyclase-stimulating G alpha protein; AHO; alternative gene product encoded by XL-exon; C20orf45; extra large alphas protein; GNAS; GNAS complex locus; GNAS1; GNAS1 gene, formerly; GNAS1, formerly; GNAS2_HUMAN; GPSA; GSA; GSP; guanine nucleotide binding protein (G protein), alpha stimulating activity polypeptide 1; guanine nucleotide regulatory protein; Guanine nucleotide-binding protein G(s) subunit alpha isoforms short; guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas; NESP; neuroendocrine secretory protein; PHP1A; PHP1B; PHP1C; POH; protein ALEX; secretogranin VI