Recombinant Human High affinity cAMP-specific and IBMX-insensitive 3′,5′-cyclic phosphodiesterase 8A (PDE8A), Truncated

Uniprot Id

O60658

Target Species

Human

Target Name

PDE8A

Target Full Name

High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A

Target Function

Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in maintaining basal levels of the cyclic nucleotide and/or in the cAMP regulation of germ cell development. Binding to RAF1 reduces RAF1 'Ser-259' inhibitory-phosphorylation and stimulates RAF1-dependent EGF-activated ERK-signaling. Protects against cell death induced by hydrogen peroxide and staurosporine.

Target Protein Families

Cyclic nucleotide phosphodiesterase family, PDE8 subfamily

Target Tissue Specificity

Expressed in most tissues except thymus and peripheral blood leukocytes. Highest levels in testis, ovary, small intestine and colon.

Target Synonyms

5''-cyclic phosphodiesterase 8A; cAMP specific cyclic nucleotide phosphodiesterase 8A ; FLJ16150; High affinity cAMP specific and IBMX insensitive 3'5' cyclic phosphodiesterase 8A ; High affinity cAMP-specific and IBMX-insensitive 3''; HsT19550; PDE 8A; PDE8A; PDE8A_HUMAN; Phosphodiesterase 8A ; Phosphodiesterase8A; Weakly similar to 3'5' cyclic nucleotide phosphodiesterase

Target Background

The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE8 subfamily. This PDE hydrolyzes the second messenger, cAMP, which is a regulator and mediator of a number of cellular responses to extracellular signals. Thus, by regulating the cellular concentration of cAMP, this protein plays a key role in many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.