Recombinant Human Homeobox protein DLX-1 (DLX1)

Uniprot Id

P56177

Target Species

Human

Target Name

DLX1

Target Full Name

Homeobox protein DLX-1

Target Function

Plays a role as a transcriptional activator or repressor. Inhibits several cytokine signaling pathways, such as TGFB1, activin-A/INHBA and BMP4 by interfering with the transcriptional stimulatory activity of transcription factors, such as MSX2, FAST2, SMAD2 and SMAD3 during hematopoietic cell differentiation. Plays a role in terminal differentiation of interneurons, such as amacrine and bipolar cells in the developing retina. Likely to play a regulatory role in the development of the ventral forebrain. May play a role in craniofacial patterning and morphogenesis and may be involved in the early development of diencephalic subdivisions.

Target Subcellular Location

Nucleus.

Target Protein Families

Distal-less homeobox family

Target Tissue Specificity

Expressed in hematopoietic cell lines.

Target Synonyms

DII B; Distal less homeo box 1; Distal less homeobox 1; Distal-less homeobox gene 1a; Dlx 1; Dlx; Dlx1; Dlx1 distal-less homeobox 1; DLX1_HUMAN; Homeo box protein DLX1; Homeobox protein DLX 1; Homeobox protein DLX-1; Homeobox protein Dlx1a; Homeodomain transcription factor DLX1 ; MGC189409; OTTHUMP00000082494; OTTHUMP00000082497; OTTMUSP00000014202; RP23-419H3.3