Recombinant Human Homeobox protein Hox-D3 (HOXD3)

Uniprot Id

P31249

Target Species

Human

Target Name

HOXD3

Target Full Name

Homeobox protein Hox-D3

Target Function

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Target Subcellular Location

Nucleus.

Target Protein Families

Antp homeobox family

Target Synonyms

Homeo box D3 ; Homeobox D3; Homeobox protein Hox D3; Homeobox protein Hox-4A; Homeobox protein Hox-D3; Homeobox protein HoxD3; Homeodomain protein; HOX 1D; HOX 4; Hox 4.1; Hox 4A; HOX D3; Hox-4.1 mouse homolog of ; HOX1D; HOX4; Hox4.1; HOX4A; HOXD 3; HOXD3; HXD3_HUMAN; MGC10470

Target Background

This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes, consisting of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXD genes located at 2q31-2q37 chromosome regions. Deletions that removed the entire HOXD gene cluster or 5' end of this cluster have been associated with severe limb and genital abnormalities. The protein encoded by this gene may play a role in the regulation of cell adhesion processes.