Recombinant Human Ileal sodium/bile acid cotransporter (SLC10A2), Truncated

Uniprot Id

Q12908

Target Species

Human

Target Name

SLC10A2

Target Full Name

Ileal sodium/bile acid cotransporter

Target Function

Plays a critical role in the sodium-dependent reabsorption of bile acids from the lumen of the small intestine. Plays a key role in cholesterol metabolism.

Target Involvement

Primary bile acid malabsorption (PBAM)

Target Subcellular Location

Membrane; Multi-pass membrane protein.

Target Protein Families

Bile acid:sodium symporter (BASS) (TC 2.A.28) family

Target Synonyms

Apical sodium dependent bile acid transporter; Apical sodium- dependent bile acid transporter; Apical sodium-dependent bile acid transporter; ASBT; IBAT; ileal; ileal apical sodium-dependent bile acid transporter; Ileal Na(+)/bile acid cotransporter; Ileal sodium dependent bile acid transporter; Ileal sodium-dependent bile acid transporter; Ileal sodium/bile acid cotransporter; ISBT; Na(+)-dependent ileal bile acid transporter; Na+ bile acid cotransporter; Na+ dependent ileal bile acid transporter; NTCP2; NTCP2_HUMAN; PBAM; SLC10A2; Sodium/taurocholate cotransporting polypeptide; Sodium/taurocholate cotransporting polypeptide; ileal; solute carrier family 10 (sodium/bile acid cotransporter family); Solute carrier family 10 (sodium/bile acid cotransporter family); member 2; Solute carrier family 10 member 2

Target Background

This gene encodes a sodium/bile acid cotransporter. This transporter is the primary mechanism for uptake of intestinal bile acids by apical cells in the distal ileum. Bile acids are the catabolic product of cholesterol metabolism, so this protein is also critical for cholesterol homeostasis. Mutations in this gene cause primary bile acid malabsorption (PBAM); muatations in this gene may also be associated with other diseases of the liver and intestines, such as familial hypertriglyceridemia (FHTG).