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| Cat.No | ACP17076 | Target Name | IER5 |
|---|---|---|---|
| Target Synonyms | IER5; PP4583; SBBI48; Immediate early response gene 5 protein | Form | Lyophilized powder |
| Expression System | Custom Production. Please inquire and provide the desire expression system. | Expression Range | 1-327 |
| Protein Length | Full length protein | Purity | >85% (SDS-PAGE) |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q5VY09 |
|---|
Uniprot Id
Q5VY09
Target Species
Human
Target Name
IER5
Target Full Name
Immediate early response gene 5 protein
Target Function
Plays a role as a transcription factor. Mediates positive transcriptional regulation of several chaperone genes during the heat shock response in a HSF1-dependent manner. Mediates negative transcriptional regulation of CDC25B expression. Plays a role in the dephosphorylation of the heat shock factor HSF1 and ribosomal protein S6 kinase (S6K) by the protein phosphatase PP2A. Involved in the regulation of cell proliferation and resistance to thermal stress. Involved in the cell cycle checkpoint and survival in response to ionizing radiation. Associates with chromatin to the CDC25B promoter.
Target Subcellular Location
Nucleus. Cytoplasm.
Target Protein Families
IER family
Target Tissue Specificity
Expressed in acute myeloid leukemia (AML) cells.
Target Synonyms
IER5; PP4583; SBBI48; Immediate early response gene 5 protein
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