Recombinant Human Inactive serine/threonine-protein kinase VRK3 (VRK3)

Uniprot Id

Q8IV63

Target Species

Human

Target Name

VRK3

Target Full Name

Serine/threonine-protein kinase VRK3

Target Function

Inactive kinase that suppresses ERK activity by promoting phosphatase activity of DUSP3 which specifically dephosphorylates and inactivates ERK in the nucleus.

Target Subcellular Location

Nucleus.

Target Protein Families

Protein kinase superfamily, CK1 Ser/Thr protein kinase family, VRK subfamily

Target Synonyms

Inactive serine/threonine-protein kinase VRK3; Serine/threonine protein kinase VRK3; Serine/threonine-protein pseudokinase VRK3; Vaccinia related kinase 3; Vaccinia-related kinase 3; Vrk3; VRK3_HUMAN

Target Background

This gene encodes a member of the vaccinia-related kinase (VRK) family of serine/threonine protein kinases. In both human and mouse, this gene has substitutions at several residues within the ATP binding motifs that in other kinases have been shown to be required for catalysis. In vitro assays indicate the protein lacks phosphorylation activity. The protein, however, likely retains its substrate binding capability. This gene is widely expressed in human tissues and its protein localizes to the nucleus. Alternative splicing results in multiple transcripts encoding different isoforms.