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| Cat.No | ACP06182 | Target Name | ITPR3 |
|---|---|---|---|
| Target Synonyms | 4, 4; 5-trisphosphate receptor; 5-trisphosphate receptor type 3; FLJ36205; Inositol 1; Inositol 1, 5 trisphosphate receptor type 3; InsP3R3; IP3 receptor; IP3 receptor isoform 3; IP3R 3; IP3R; IP3R3; ITPR 3; ITPR3; ITPR3_HUMAN; Type 3 inositol 1; Type 3 inositol 1, 5 trisphosphate receptor; Type 3 InsP3 receptor | Form | Lyophilized powder |
| Expression System | Custom Production. Please inquire and provide the desire expression system. | Protein Length | Partial |
| Purity | >85% (SDS-PAGE) | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q14573 |
|---|
Uniprot Id
Q14573
Target Species
Human
Target Name
ITPR3
Target Full Name
Inositol 1,4,5-trisphosphate-gated calcium channel ITPR3
Target Function
Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium.
Target Subcellular Location
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Target Protein Families
InsP3 receptor family
Target Tissue Specificity
Expressed in intestinal crypt and villus epithelial cells.
Target Synonyms
4; 5-trisphosphate receptor; 5-trisphosphate receptor type 3; FLJ36205; Inositol 1; Inositol 1,4,5 trisphosphate receptor type 3; InsP3R3; IP3 receptor; IP3 receptor isoform 3; IP3R 3; IP3R; IP3R3; ITPR 3; ITPR3; ITPR3_HUMAN; Type 3 inositol 1; Type 3 inositol 1,4,5 trisphosphate receptor; Type 3 InsP3 receptor
Target Background
This gene encodes a receptor for inositol 1, 4, 5-trisphosphate, a second messenger that mediates the release of intracellular calcium. The receptor contains a calcium channel at the C-terminus and the ligand-binding site at the N-terminus. Knockout studies in mice suggest that type 2 and type 3 inositol 1, 4, 5-trisphosphate receptors play a key role in exocrine secretion underlying energy metabolism and growth.
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