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An entire inositol hexakisphosphate kinase 1 (IP6K1)?ORF inserted a 6xHis-SUMO-tag at the N-terminus was expressed in E.coli. The generated protein is the recombinant full-length fusion IP6K1 containing 1-441aa of human IP6K1. The SDS-PAGE analysis measured its purity up to 90%, and it has a calculated molecular mass of 66.2 kDa. In-stock IP6K1 proteins are offered now. This recombinant IP6K1 protein may be used to generate specific antibodies or in the studies of IP6K1-mediated signal transduction. IP6K1 is most abundantly expressed in the brain. IP6K1 and its product, 5-diphosphoinositol pentakisphosphate (5-IP7), act as key physiological determinants for suppression of presynaptic vesicle exocytosis and stimulation of endocytosis at central synapses. Besides, IP6K1 can directly bind and stimulate glycogen synthase kinase 3 (GSK3) in a non-catalytic manner. Min-Gyu Kim etc. showed that IP6K1 plays a role in the control of sensorimotor gating and short-term fear memory.
An entire inositol hexakisphosphate kinase 1 (IP6K1)?ORF inserted a 6xHis-SUMO-tag at the N-terminus was expressed in E.coli. The generated protein is the recombinant full-length fusion IP6K1 containing 1-441aa of human IP6K1. The SDS-PAGE analysis measured its purity up to 90%, and it has a calculated molecular mass of 66.2 kDa. In-stock IP6K1 proteins are offered now. This recombinant IP6K1 protein may be used to generate specific antibodies or in the studies of IP6K1-mediated signal transduction.
IP6K1 is most abundantly expressed in the brain. IP6K1 and its product, 5-diphosphoinositol pentakisphosphate (5-IP7), act as key physiological determinants for suppression of presynaptic vesicle exocytosis and stimulation of endocytosis at central synapses. Besides, IP6K1 can directly bind and stimulate glycogen synthase kinase 3 (GSK3) in a non-catalytic manner. Min-Gyu Kim etc. showed that IP6K1 plays a role in the control of sensorimotor gating and short-term fear memory.
| Cat.No | ACP02394 | Target Name | IP6K1 |
|---|---|---|---|
| Form | Liquid or Lyophilized powder | Expression System | E.coli |
| Expression Range | 1-441aa | Mol Weight | 66.2kDa |
| Protein Length | Full length | Purity | Greater than 90% as determined by SDS-PAGE. |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q92551 |
|---|
Uniprot Id
Q92551
Target Species
Human
Target Name
IP6K1
Target Full Name
Inositol hexakisphosphate kinase 1
Target Function
Converts inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5). Converts 1,3,4,5,6-pentakisphosphate (InsP5) to PP-InsP4.
Target Subcellular Location
Cytoplasm. Nucleus.
Target Protein Families
Inositol phosphokinase (IPK) family
Target Research Area
Signal Transduction
Target Synonyms
ATP:1D myo inositol hexakisphosphate phosphotransferase; IHPK1; Inositol hexakisphosphate kinase 1; Inositol hexaphosphate kinase 1; InsP6; InsP6 kinase 1; Ip6k1; IP6K1_HUMAN; Itpk6; Pi uptake stimulator; PiUS
Target Background
This gene encodes a member of the inositol phosphokinase family. The encoded protein may be responsible for the conversion of inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5). It may also convert 1, 3, 4, 5, 6-pentakisphosphate (InsP5) to PP-InsP4. Alternatively spliced transcript variants have been described.
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