Recombinant Human Integrin-linked kinase-associated serine/threonine phosphatase 2C (ILKAP)

Uniprot Id

Q9H0C8

Target Species

Human

Target Name

ILKAP

Target Full Name

Integrin-linked kinase-associated serine/threonine phosphatase 2C

Target Function

Protein phosphatase that may play a role in regulation of cell cycle progression via dephosphorylation of its substrates whose appropriate phosphorylation states might be crucial for cell proliferation. Selectively associates with integrin linked kinase (ILK), to modulate cell adhesion and growth factor signaling. Inhibits the ILK-GSK3B signaling axis and may play an important role in inhibiting oncogenic transformation.

Target Subcellular Location

Cytoplasm.

Target Protein Families

PP2C family

Target Tissue Specificity

Widely expressed. Highest levels expressed in striated muscle. Much lower levels evident in various smooth muscle tissues.

Target Research Area

Signal Transduction

Target Synonyms

DKFZp434J2031; FLJ10181; ILKAP; ILKAP_HUMAN; ILKAP2; ILKAP3; Integrin linked kinase associated phosphatase; Integrin linked kinase associated serine/threonine phosphatase 2C; Integrin linked kinase associated serine/threonine phosphatase; Integrin-linked kinase-associated serine/threonine phosphatase 2C; MGC4846; PP2C DELTA; Protein phosphatase 2c delta isozyme

Target Background

The protein encoded by this gene is a protein serine/threonine phosphatase of the PP2C family. This protein can interact with integrin-linked kinase (ILK/ILK1), a regulator of integrin mediated signaling, and regulate the kinase activity of ILK. Through the interaction with ILK, this protein may selectively affect the signaling process of ILK-mediated glycogen synthase kinase 3 beta (GSK3beta), and thus participate in Wnt signaling pathway.