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Unlock the potential of your epigenetics and nuclear signaling research with our premium Recombinant Human IFNAR2 protein, a vital component of the type I interferon receptor. IFNAR2 plays a critical role in immune regulation and antiviral response, making it an essential protein in the study of the interferon signaling pathway and related immune system disorders. Our Recombinant Human IFNAR2 protein features the extracellular domain (27-243 amino acids) to ensure optimal bioactivity and receptor binding. Expressed in E. coli, this protein comes with a convenient N-terminal 6xHis-SUMO tag for efficient purification and detection without compromising its native structure or function. With a purity greater than 90% as determined by SDS-PAGE, our Recombinant Human IFNAR2 protein delivers accurate and reliable results to support your research endeavors. Choose from liquid or lyophilized powder forms to best suit your experimental needs.
Unlock the potential of your epigenetics and nuclear signaling research with our premium Recombinant Human IFNAR2 protein, a vital component of the type I interferon receptor. IFNAR2 plays a critical role in immune regulation and antiviral response, making it an essential protein in the study of the interferon signaling pathway and related immune system disorders.
Our Recombinant Human IFNAR2 protein features the extracellular domain (27-243 amino acids) to ensure optimal bioactivity and receptor binding. Expressed in E. coli, this protein comes with a convenient N-terminal 6xHis-SUMO tag for efficient purification and detection without compromising its native structure or function. With a purity greater than 90% as determined by SDS-PAGE, our Recombinant Human IFNAR2 protein delivers accurate and reliable results to support your research endeavors. Choose from liquid or lyophilized powder forms to best suit your experimental needs.
| Cat.No | ACP03574 | Target Name | IFNAR2 |
|---|---|---|---|
| Form | Liquid or Lyophilized powder | Expression System | E.coli |
| Expression Range | 27-243aa | Mol Weight | 40.8kDa |
| Protein Length | Extracellular Domain | Purity | Greater than 90% as determined by SDS-PAGE. |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | P48551 |
|---|
Uniprot Id
P48551
Target Species
Human
Target Name
IFNAR2
Target Full Name
Interferon alpha/beta receptor 2
Target Function
Associates with IFNAR1 to form the plasma membrane receptor in the type I interferon signaling pathway. Directly involved in signal transduction through its association with the TYR kinase JAK1. Involved in interferon-mediated STAT1, STAT2 and STAT3 activation.; Potent inhibitor of type I IFN receptor activity.
Target Involvement
Immunodeficiency 45 (IMD45)
Target Subcellular Location
[Isoform 1]: Cell membrane; Single-pass type I membrane protein.; [Isoform 2]: Cell membrane; Single-pass type I membrane protein.; [Isoform 3]: Secreted.
Target Protein Families
Type II cytokine receptor family
Target Tissue Specificity
Isoform 3 is detected in the urine (at protein level). Expressed in blood cells. Expressed in lymphoblastoid and fibrosarcoma cell lines.
Target Research Area
Epigenetics and Nuclear Signaling
Target Synonyms
Human interferon alpha/beta receptor; IFN alpha REC; IFN R; IFN-alpha binding protein; IFN-alpha/beta receptor 2; IFN-R-2; IFNABR ; IFNAR2; IFNARB ; IFNR; INAR2_HUMAN; Interferon (alpha beta and omega) receptor 2; Interferon alpha binding protein; Interferon alpha/beta receptor 2; Interferon alpha/beta receptor beta chain; Type I interferon receptor 2; Type I interferon receptor
Target Background
The protein encoded by this gene is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulates Janus protein kinases, which in turn phosphorylate several proteins, including STAT1 and STAT2. The protein belongs to the type II cytokine receptor family. Mutations in this gene are associated with Immunodeficiency 45.
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